Against Senolytics

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There is no consensus in science that is so strong as to have no heretics. So here we have an interview with a naysayer on the matter of senolytic treatments, who argues that the loss of senescent cells in aged tissues will cause more harm to long-term health than the damage they will do by remaining. To be clear, I think this to be a ridiculous argument given the present evidence. To make it one has to declare the existing results showing extension of healthy life span in mice to be something other than credible data, which just isn’t the case. Further, it seems shaky on theoretical grounds to suggest that removal of something like 1% of cells will put onerous stress on the remaining 99%, particularly given that the 1% were contributing to declining stem cell activity via inflammatory signaling. All told, it is hard to take seriously the idea that loss of senescent cells can possibly produce greater degrees of dysfunction in tissue than is caused by the inflammatory signaling of senescent cells.


Your new review on senolytics suggests that senolytics may cause more harm than good. Can you summarize your objections and concerns?

Here is the argument: 1) theoretically, senolytics should make things worse and 2) the available data support this theoretical concern. To use an analogy, imagine that you have a factory in which 10 of the 100 factory workers are feeling overworked and tired. Furthermore, their complaints are disrupting the other workers. You have two possible interventions. You can: (a) Fire the 10 workers, thereby removing the complainers. The result is that the remaining 90 workers are now overworked, and they, too, begin to complain. You end up with 30 workers who are now complaining and disrupting your factory. This is the senolytic approach. (b) Improve the health and conditions of the 10 workers who are overworked and complaining. You now have 100 workers who are doing an excellent job. This is the telomerase therapy approach.

In the first case, your factory has a problem and you make it worse. In the second case, your factory has a problem and you solve the problem. This figure from my new paper illustrates the same point in terms of nine cells subjected to senolytics, with the result being temporary short-term improvement followed by decline and a worse situation than we started with.

This does not take into account the idea of replacing that pool of “workers” by bringing in fresh stem cells.

You have to keep a few points in mind. 1) Will the stem cells populate as desired? 2) If you do get a stem cell population, that requires cell division, which shortens telomeres, which accelerates cell senescence, and once again you have accelerated pathology. 3) Why would you bother recruiting stem cells when you can much more easily reset cell senescence in the resident cells of the tissue? 4) The long-term data (what there is of it) supports the failure of senolytics. Again: remember where those “new cells” come from: you are accelerating senescence in the stem cell pool. The only way to “replace them with healthy working cells” is to simply and effectively reset gene expression, taking senescing cells and turning them into functionally young cells.

It seems that we can only speculate on these issues, as these long-term follow-ups have not yet been done. However, senolytics have been shown to increase median lifespan and healthspan in murine models.

I don’t see any credible data that supports the contention that “senolytics have been shown to increase median lifespan and healthspan in murine models”.

Link: https://www.leafscience.org/are-senolytics-potentially-damaging-for-longevity/

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Tap Into the Power of Nutrient Synergy: Combining Supplements to Maximize Health Benefits

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Tap Into the Power of Nutrient Synergy: Combining Supplements to Maximize Health Benefits
Dr. Heidi Yanoti, DC – Life Extension Senior Wellness Specialist

Nutrient synergy is when two or more different nutrients work together to produce a greater effect than you would expect from either nutrient alone. Some nutrients can greatly enhance each other’s absorption. Others just work far better in teams. Here are some specific nutrients that may work in concert to produce health benefits far exceeding their individual benefits.

VITAMIN C and IRON – The Dynamic Duo

Vitamin C enhances the absorption of iron.1 Whether we get our iron from food sources or supplements, the presence of Vitamin C helps ensure that iron gets into circulation. The importance of iron absorption cannot be overstated; iron is one of the most crucial of minerals. Without iron, the hemoglobin in our red blood cells would not be able to deliver oxygen to our tissues.2

VITAMIN D, VITAMIN K and CALCIUM – Keys to Strong Bones and a Healthy Heart

Calcium is an essential nutrient for bone building. Some people get enough calcium from food, others need to supplement. No matter what your source of calcium, it cannot be absorbed without adequate vitamin D.3 But once vitamin D has helped get your calcium into circulation, we need vitamin K to get that calcium from the bloodstream to the bones. Vitamin K shuttles calcium away from the blood vessels, where it could lead to potentially deadly calcium deposits, and delivers it to our skeleton for strong, dense bones.4

GREEN TEA and QUERCETIN – Protective Plant Compounds

Quercetin is an antioxidant found in many fruits and vegetables. Green tea is a beverage that has been enjoyed for centuries for its metabolic and immune support. Both compounds fight damaging free radicals and inflammation, but their protective abilities for our cells increase when they are combined. Quercetin has been shown to enhance the absorption of EGCG, potentially the most important constituent of green tea.5,6 Using these nutrients together may amplify their ability to protect our cells and our DNA from harmful inflammatory factors.7

COQ10 and PQQ – A Biological Power Boost

CoQ10 and PQQ may work synergistically towards healthy aging at the most basic level, the cellular level. Most of our cells contain mitochondria, which are energy factories that create the power to keep our body running. Mitochondria become damaged and even die off as we get older, and this loss of potential energy production is thought to be a major contributor to the aging process.8 CoQ10 is a powerful antioxidant that fuels and protects our mitochondria.9PQQ is an essential micronutrient that has been shown to support mitochondrial regeneration.10 Together, CoQ10 and PQQ may work to help support this essential part of healthy aging, cellular energy production.

B VITAMINS – It Takes Eight to be Great

There are 8 B vitamins that each perform essential functions to maintain health and work together with closely interrelated roles in our biochemistry. The many ways that the members of the B vitamin family work together are too numerous to list, but we can highlight some examples of their synergy. Vitamins B12 and B9 (also known as folate) work together to support healthy cell division and replication, are needed for healthy red blood cell production to oxygenate our tissues, and are essential for breaking down homocysteine to protect our heart and arteries.11-13 Vitamins B1 (thiamine), B2 (riboflavin) and B5 play a crucial role in the cellular metabolic process that turn food into energy.14 B6 and B3 (niacin) are essential to a healthy brain chemistry. Both are required to manufacture tryptophan, a precursor to the feel-good neurotransmitter serotonin for healthy mood.15,16 Several of the B-Vitamins including biotin have been shown to work together to support healthy hair growth, as a deficiency could lead to hair loss.17 As we study the way these nutrients work in concert and depend on each other, it becomes clear that we must ensure that all 8 members of the B vitamin group are part of our daily regimen.18

THE WHOLE IS GREATER THAN THE SUM OF ITS PARTS

This expression applies perfectly to the idea of nutrient synergy. You can maximize the benefits of a healthy diet and supportive supplement regimen by being aware of how you combine your nutrients to support their synergistic actions.

About the Author: Heidi Yanoti earned her Doctor of Chiropractic degree from Life University. She has been a Senior Wellness Specialist at Life Extension for over 10 years and a lifelong advocate for alternative approaches to optimal health. She enjoys sharing this passion with Life Extension customers, helping them achieve their health goals with a focus on promoting wellness. In her spare time, she enjoys reading, films and desert hikes in her Las Vegas, Nevada, home.

References:

  1. Aging (Albany NY). 2016;8(5):1150-2.
  2. Linus Pauling Institute. Iron. Accessed 11/13/19. https://lpi.oregonstate.edu/mic/minerals/iron
  3. Linus Pauling Institute. Vitamin D. Accessed 6/7/19. https://lpi.oregonstate.edu/mic/vitamins/vitamin-D
  4. Linus Pauling Institute. Vitamin K. Accessed 6/11/19. https://lpi.oregonstate.edu/mic/vitamins/vitamin-K
  5. Food Funct. 2018 Jan 24;9(1):234-242
  6. Nutrients. 2012 Nov; 4(11): 1679–1691
  7. Phytother Res. 2019;33(3):756-767.
  8. Genes (Basel). 2017 Dec; 8(12): 398
  9. J Pharm Bioallied Sci. 2011 Jul-Sep; 3(3): 466–467
  10. J Biol Chem. 2010 Jan 1; 285(1): 142–152
  11. Mutat Res. 2012 May 1;733(1-2):21-33
  12. Linus Pauling Institute. Folate. Accessed 11/13/19. https://lpi.oregonstate.edu/mic/vitamins/folate 
  13. Linus Pauling Institute. Vitamin B12. Accessed 11/13/19. https://lpi.oregonstate.edu/mic/vitamins/vitamin-B12
  14. Chem Biol Interact. 2006 Oct 27;163(1-2):94-112
  15. Linus Pauling Institute. Vitamin B6. Accessed 11/13/19. https://lpi.oregonstate.edu/mic/vitamins/vitamin-B6
  16. Linus Pauling Institute. Niacin. Accessed 11/13/19. https://lpi.oregonstate.edu/mic/vitamins/niacin
  17. Dermatol Ther (Heidelb). 2019 Mar;9(1):51-70.
  18. Nutrients. 2016;8(2):68.

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A Role for B Cells in the Chronic Inflammation Generated by Visceral Fat Tissue

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Much of the long-term harm caused by excess visceral fat tissue is due to raised levels of chronic inflammation, the inappropriate over-activation of the immune system characteristic of both obesity and aging. Chronic inflammation accelerates the progression of near all of the common age-related conditions. There are numerous mechanisms via which fat tissue rouses an immune response: cellular debris that triggers immune cells into action; generation of excessive numbers of senescent cells; inappropriate signaling from fat cells that mimics the response to infection; infiltration of inflammatory macrophages into fat tissue; and so forth. Researchers here investigate some of the details of the way in which the immune system interacts with visceral fat, focusing on a role for B cells in spurring the inflammation that results.


Previous work found that as people age, their body’s ability to generate energy by burning belly fat is reduced. Consequently, fat that surrounds the internal organs increases in the elderly. Researchers had found that the immune cells necessary to the fat-burning process, called macrophages, were still active but their overall numbers declined as belly fat increased with aging. This latest study found that something else is happening as well. Adipose B cells in belly fat unexpectedly proliferated as animals aged, contributing to increased inflammation and metabolic decline. “These adipose B cells are a unique source of inflammation. Normally the B cells produce antibodies, and defend against infection. But with aging, the increased adipose B cells become dysfunctional, contributing to metabolic disease.”

When they are working correctly, some B cells expand as needed to protect the body from infection, and then contract to baseline. But with aging, they don’t contract in belly fat. This predisposes to diabetes and metabolic dysfunction like inability to burn fat. Researchers theorizes that this ongoing expansion may be due to increased human life expectancy – a pushing of the body’s cells beyond their evolutionary limits. Researchers discovered that adipose B cells expand by receiving signals from nearby macrophages. Relatedly, they found that by reducing the macrophage signal and by removing adipose B cells, they could reverse the expansion process, and protect against age-induced decline in metabolic health.

Link: https://news.yale.edu/2019/11/14/new-finding-offers-possibility-preventing-age-related-metabolic-disease

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A Mechanism by which Cellular Senescence Drives Pulmonary Fibrosis

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The lingering senescent cells that accumulate with age are an important contributing cause of degenerative aging. If nothing else, their secretions generate a significant fraction of the chronic inflammation of aging, disrupting tissue function and immune function. Chronic inflammation is in turn well known to accelerate all of the most common age-related conditions. Fibrosis is a consequence of dysfunctional tissue maintenance and regeneration, in which scar-like deposits form, degrading tissue function. There is good evidence for fibrotic diseases, such as those of the lung, kidney, and heart, to be driven in large part by the presence of senescent cells. This is good news for patients, as while there is little that can be done to treat these conditions in the practice of medicine at the present time, senolytic therapies to clear senescent cells may well help to turn back fibrosis.


Accumulation of senescent cells is associated with the progression of pulmonary fibrosis but mechanisms accounting for this linkage are not well understood. To explore this issue, we investigated whether a class of biologically active profibrotic lipids, the leukotrienes (LT), is part of the senescence-associated secretory phenotype. The analysis of conditioned medium (CM) lipid extracts and gene expression of LT biosynthesis enzymes revealed that senescent cells secreted LT regardless of the origin of the cells or the modality of senescence induction.

The synthesis of LT was biphasic and followed by anti-fibrotic prostaglandin (PG) secretion. The LT-rich CM of senescent lung fibroblasts induced pro-fibrotic signaling in naïve fibroblasts, which were abrogated by inhibitors of ALOX5, the principal enzyme in LT biosynthesis. The bleomycin-induced expression of genes encoding LT and PG synthases, level of cysteinyl leukotriene in the bronchoalveolar lavage, and overall fibrosis were reduced upon senescent cells removal either in a genetic mouse model or after senolytic treatment. Quantification of ALOX5+cells in lung explants obtained from idiopathic pulmonary fibrosis (IPF) patients indicated that half of these cells were also senescent (p16Ink4a+). Unlike human fibroblasts from unused donor lungs made senescent by irradiation, senescent IPF fibroblasts secreted LTs but failed to synthesize PGs.

This study demonstrates for the first time that senescent cells secrete functional LTs, significantly contributing to the LTs pool known to cause or exacerbate idiopathic pulmonary fibrosis.

Link: https://doi.org/10.1172/jci.insight.130056

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Low Magnesium Linked to Diabetes and High Blood Pressure

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Magnesium1 is involved in hundreds of biochemical reactions in your body,2,3 and deficiency can contribute to significant health problems. Two common pathologies associated with magnesium deficiency are Type 2 diabetes4,5 and heart disease.

According to one scientific review,6 low magnesium may actually be the greatest predictor of heart disease, and other recent research7 published in Open Heart journal suggests even subclinical magnesium deficiency can compromise your cardiovascular health.

As noted in a 2018 scientific review8,9 published in Open Heart journal, a “vast majority of people in modern societies are at risk for magnesium deficiency” due to “chronic diseases, medications, decreases in food crop magnesium contents, and the availability of refined and processed foods.”

According to this review, most fail to meet the recommended daily allowance (RDA) for magnesium; 48% of Americans do not get sufficient magnesium from their diet. Among postmenopausal women with osteoporosis, the rate of magnesium deficiency is 84%.10

Type 2 diabetics also tend to be more prone to magnesium deficiency, and magnesium depletion has been found in 75% of patients with poorly controlled Type 2 diabetes, the review states.11

Magnesium Protects Your Heart Health

Low magnesium has been linked to a higher risk for high blood pressure,12 stroke13 and sudden cardiac death.14 According to the Open Heart study authors,15 “most people need an additional 300 mg of magnesium per day in order to lower their risk of developing numerous chronic diseases,” and this includes heart disease and diabetes. Magnesium supports healthy heart function and helps prevent heart disease by:16

  • Combating inflammation, thereby helping prevent hardening of your arteries
  • Normalizing blood pressure
  • Improving blood flow by relaxing your arteries and preventing your blood from thickening, allowing it to flow more smoothly

Magnesium Status Impacts Diabetes and Blood Pressure

Magnesium also plays an important role in diabetes, and this is not nearly as recognized as it needs to be. Low magnesium levels have been linked to a higher risk of insulin resistance, a precursor to Type 2 diabetes,17 as it impairs your body’s ability to regulate blood sugar, which is important for the prevention of Type 2 diabetes.18,19,20,21

In one study,22 prediabetics with the highest magnesium intake reduced their risk for blood sugar and metabolic problems by 71%, compared to those with the lowest intake. High levels of insulin in the blood, common with insulin resistance, also lead to further loss of magnesium.23

Most recently, a study24 published in October 2019 in the online issue of Diabetes Research and Clinical Practice again linked low magnesium levels with both diabetes and high blood pressure, both of which are risk factors for heart disease. As reported by the authors:25

“Across the quartiles of serum magnesium from high to low, the prevalence ratios for diabetes were 1.00, 1.35, 1.88, and 2.70, respectively. The presence of hypertension significantly increased the probability of diabetes along a wide range of low serum magnesium. A low intake of MRDP [magnesium related dietary pattern] was also positively associated with diabetes and high HbA1c.”

Other Studies Linking Magnesium Status to Diabetes Risk

An earlier meta-analysis,26 published in 2007, also found that magnesium intake was inversely associated with Type 2 diabetes incidence. This analysis included seven cohort studies looking at magnesium from either food or diet and supplements combined. According to the authors:

“All but one study found an inverse relation between magnesium intake and risk of Type 2 diabetes, and in four studies the association was statistically significant.

The overall relative risk for a 100 mg day increase in magnesium intake was 0.85. Results were similar for intake of dietary magnesium and total magnesium. There was no evidence of publication bias.”

Magnesium supplementation not only can lower your risk of Type 2 diabetes, but also has been shown to improve your condition if you already have full-blown diabetes. This was demonstrated in a 2018 study27 in the journal Nutrients.

Type 2 diabetics who took 250 milligrams (mg) of magnesium per day for three months saw a significant improvement in insulin levels and HbA1C (hemoglobin A1c, which is a marker of long-term glucose control) compared to controls.

As noted by the authors,28 “The results of this study matched previous studies that concluded that daily oral Mg supplementation substantially improved insulin sensitivity by 10% and reduced blood sugar by 37%.”

Are You Deficient in Magnesium?

The best way to ascertain your magnesium status is to do an RBC magnesium test, which measures the amount of magnesium in your red blood cells, along with tracking any signs and symptoms of magnesium deficiency, such as:29,30

Seizures; muscle spasms, especially “charley horses” or spasms in your calf muscle that happen when you stretch your leg, and/or eye twitches

Numbness or tingling in your extremities

Insulin resistance

High blood pressure, heart arrhythmias and/or coronary spasms

Increased number of headaches and/or migraines

Low energy, fatigue and/or loss of appetite

The Trousseau sign31 — To check for this sign, a blood pressure cuff is inflated around your arm. The pressure should be greater than your systolic blood pressure and maintained for three minutes.

By occluding the brachial artery in your arm, spasms in your hand and forearm muscles are induced. If you are magnesium deficient, the lack of blood flow will cause your wrist and metacarpophalangeal joint to flex and your fingers to adduct (illustrated in the video below).

A more exhaustive list can be found in Dr. Carolyn Dean’s blog post, “Gauging Magnesium Deficiency Symptoms,”32 which will give you a checklist to go through every few weeks. This will also help you gauge how much magnesium you need to resolve your deficiency symptoms.

Get Tested Today

GrassrootsHealth, which is conducting consumer-sponsored research into vitamin D and omega-3, has now added magnesium to its nutrient research.

Their Vitamin D, Magnesium and Omega 3 PLUS Elements test kit is an excellent and cost-effective way to check the status of several vital nutrients, along with the essential minerals selenium, zinc and copper and the harmful heavy metals cadmium, lead and mercury.

Each kit contains instructions for how to collect your blood sample. You then mail in your sample and fill out a quick online health questionnaire through GrassrootsHealth.

Your participation in this research project will enable GrassrootsHealth researchers to provide accurate data about the magnesium status in the population, the level at which disease prevention is actually obtained, and guidance on dosing to achieve optimal levels.

All of this is crucial information that can go a long way toward improving public health. As explained by GrassrootsHealth, questions about magnesium that this particular project aims to provide answers for include:33

  • What specific health outcomes are associated with this nutrient for me, for the total group?
  • How can I figure out how much to take? What’s the dose-response relationship for all? For me?
  • Does it matter if I’m also taking vitamin D? Omega-3?
  • Does it matter what compound of this nutrient I take? What time of day? How often?
  • What are the demonstrated health outcomes used to create this nutrient’s recommended range?

Your test results will be emailed to you in about 10 to 20 days after your samples are received. Your health data are used anonymously. Please note that 100% of the proceeds from the kits go to fund the research project. I do not charge anything extra as a distributor of these test kits.

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Why Most People Need More Magnesium

One of the reasons why magnesium insufficiency or deficiency is so common, both among adults34 and teens,35 is in part due to the fact that most people don’t eat enough plant foods. Magnesium is actually part of the chlorophyll molecule responsible for the plant’s green color.

If you frequently eat processed foods, your risk of deficiency is magnified. That said, even if you eat plenty of greens you might still need to take a supplement, as most foods are grown in mineral-depleted soils and are thus much lower in magnesium than they have been historically.

Magnesium absorption is also dependent on having sufficient amounts of selenium, parathyroid hormone and vitamins B6 and D, and is hindered by excess ethanol, salt, coffee and phosphoric acid in soda.

Sweating, stress, lack of sleep, excessive menstruation, certain drugs (especially diuretics and proton-pump inhibitors) also deplete your body of magnesium.36 For these reasons, most people probably need to take supplemental magnesium. Taking a magnesium supplement is particularly advisable if you:37

Experience symptoms of insufficiency or deficiency38

Have high blood pressure

Engage in strenuous exercise on a regular basis — Research39 shows just six to 12 weeks of strenuous physical activity can result in magnesium deficiency, likely due to increased magnesium demand in your skeletal muscle

Are taking diuretics or medication for high blood pressure, especially thiazides, which have been shown to induce undetectable magnesium deficiency40 (while patients may have normal or even high serum magnesium, their bodies are actually depleted of magnesium)

Have had or are planning heart transplant or open heart surgery

Are at risk for or have had a heart attack, or if you experience ventricular arrhythmia

Have congestive heart failure

Are insulin resistant or diabetic (as this increases magnesium depletion)

Eat More Magnesium-Rich Foods

The recommended dietary allowance for magnesium is around 310 to 420 mg per day depending on your age and sex,41 but many experts believe you may need 600 to 900 mg per day.42

Personally, I believe many may benefit from amounts as high as 1 to 2 grams (1,000 to 2,000 mg) of elemental magnesium per day, as most of us have electromagnetic field exposures that simply cannot be mitigated, and the extra magnesium may help lower the damage from that exposure.

If your veggie consumption is low to begin with, consider including more magnesium-rich vegetables in your daily diet. Dark-green leafy vegetables lead the pack when it comes to magnesium content, and juicing your greens is an excellent way to boost your intake.

Other foods that are particularly rich in magnesium include natto, raw cacao nibs, unsweetened cocoa powder, avocados, pumpkin and sesame seeds, and herbs like chives and basil.43 One way to check your daily magnesium intake from foods is to use a free online nutritional tracker such as Cronometer.

Other Ways to Boost Your Magnesium Level

If your magnesium intake from food is found lacking, it would certainly be wise to supplement, either orally or topically. For oral supplementation, my personal preference is magnesium threonate, as it appears to be the most efficient at penetrating cell membranes, including your mitochondria and blood-brain barrier.

As a general rule, I recommend starting out on a dose of 200 mg of oral magnesium citrate per day, gradually increasing your dose until you develop slightly loose stools. To use this method, you need to use magnesium citrate, as it’s known for having a laxative effect. Once you know your cutoff, you can switch to other forms if you like. Other effective ways to boost your magnesium level include:

Taking Epsom salt (magnesium sulfate) baths, as the magnesium will effectively absorb through your skin.

Using a topical solution — I prepare a supersaturated solution of Epsom salt by dissolving 7 tablespoons of the salt into 6 ounces of water and heating it until all the salt has dissolved. I pour it into a dropper bottle and then apply it to my skin and rub fresh aloe leaves over it to dissolve it.

This is an easy and inexpensive way to increase your magnesium and will allow you to get higher dosages into your body without having to deal with its laxative effects.

Magnesium can be taken with or without food. If you’re also taking calcium, take them together. If you exercise regularly, consider taking your calcium and magnesium in a ratio of one part calcium to two parts magnesium with your pre-workout meal.

While the ideal ratio of magnesium to calcium is thought to be 1-to-1, most people get far more calcium than magnesium from their diet; hence, your need for supplemental magnesium may be two to three times greater than calcium.

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Weekly Health Quiz: Coke, Google and Autism

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1 Which of the following nutrients is crucial for the prevention of osteoporosis and cardiovascular events such as heart attack and stroke?

  • Vitamin K2

    Vitamin K2 inhibits arterial calcification and improves arterial flexibility, thereby reducing your risk of a cardiovascular event (such as a heart attack) or death. It’s also important for the prevention of osteoporosis. Learn more.

  • Omega-6
  • Omega-3
  • Vitamin K1

2 Which of the following has been linked to a significantly increased risk of ADHD and autism when consumed during pregnancy?

  • Statins
  • Acetaminophen

    Recent research found that, compared to children of mothers with the lowest acetaminophen burden, children of mothers with the greatest exposure had a 286% higher risk for ADHD and a 362% higher risk for autism spectrum disorder (ASD) by the time they were about 9 years old. Previous studies have also linked acetaminophen use during pregnancy with a higher risk for ADHD and other behavioral problems. Learn more.

  • Vitamin D supplements
  • Blood pressure medication

3 How many safety studies has the Federal Communications Commission performed to ascertain the health and environmental risks of 5G?

  • 6
  • 19
  • None

    No 5G safety studies have been conducted or funded by the Federal Communications Commission or the telecom industry, and none is planned. Learn more.

  • Over 300

4 Which of the following have recently been found to be interconnected, exerting a powerful influence over each other?

  • Brain, sinuses and esophagus
  • Gut microbiome and activity level
  • Renal system and muscular activity
  • Gut microbiome, sleep, immune function and cognition

    Recent research shows the composition of your gut microbiome, the quality and quantity of your sleep, your immune function and cognition are all connected and exert a powerful influence over each other. Learn more.

5 Which of the following strategies will optimize fat loss, according to more recent science?

  • Skip breakfast and exercise on an empty stomach in the morning

    Evidence suggests you can reap important health benefits by exercising in a fasted state. Skipping breakfast and exercising on an empty stomach has been shown to boost fat loss, compared to exercising after breakfast. Learn more.

  • Eat a carbohydrate-based breakfast before exercising in the morning
  • Eat a high-fat diet before exercising in the morning
  • Skip breakfast and lunch, and exercise after dinner

6 The Coca-Cola Company

  • is committed to ending plastic pollution
  • is doing little about the plastic pollution it causes

    Coca-Cola’s many single-use plastic bottle beverages cause much of the world’s plastic waste and the company is doing little about it. Learn more.

  • has significantly reduced worldwide plastic pollution
  • helps world hunger through selling low-cost beverages

7 Name one way by which Google can influence and manipulate U.S. elections without anyone noticing:

  • Political advertising
  • Lobbying
  • Search engine manipulation (biased search rankings)

    Google tools such as autofill search recommendations can be used to sway public opinion on political (and other topics), which can have significant political consequences. Research shows biased search rankings can shift voting preferences of undecided voters by 20% or more, and that people will be completely unaware of having been manipulated. Learn more.

  • Entering a Manchurian candidate into the presidential race

 

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The 6-Minute Rule for Heart Supplements

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Nitric oxide is an essential substance for your cardiovascular and sexual health. Nitric oxide is a gas that unwinds and expands your capillary, reduces high blood pressure and increases blood flow. Increasing production of nitric oxide secures against cardiovascular illness and impotence. Arginine and citrulline are 2 amino acids that play important functions in producing nitric oxide.  nitric oxide

A close-up of pistachios on wooden table. Credit: Valengilda/i Stock/Getty Images Arginine is a semi-essential amino acid kids require from foods and adults can make in the body. Arginine is a precursor to nitric oxide. Increasing dietary intake of arginine from food and supplements increases production of nitric oxide. Taking arginine supplements improves blood pressure and blood flow and lowers danger of cardiovascular disease.

4 Easy Facts About Cardiovascular Health Shown

The researchers found arginine supplements increase nitric oxide production, minimize inflammation and enhance cardiovascular function. Citrulline increases nitric oxide production by increasing arginine levels, which in turn transforms into nitric oxide. Taking citrulline supplements minimizes your high blood pressure. Researchers at Florida State University in Tallahassee discovered that oral citrulline supplements lowers high blood pressure, according to research published in the “American Journal of High Blood Pressure” in January 2010.

The researchers report this finding is substantial because aortic high blood pressure better reflects cardiovascular danger than brachial blood pressure, which is much easier to determine and is the more conventional measurement. Arginine is discovered in meat, fish, dairy, eggs, nuts, seeds, entire grains, chocolate, carob and legumes, particularly soy; however, research is limited in showing the types of foods consisting of arginine that will increase nitric oxide production.

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Erectile dysfunction is connected with low levels of nitric oxide production, due in part to dietary arginine deficiency, according to research study by scientists at the Tokyo Medical and Dental University in Japan and published in the “International Journal of Urology” in February 2008. Scientists at the Ataturk Teaching and Research Study Healthcare Facility in Ankara, Turkey, discovered that married men with erectile dysfunction who take in Antep pistachios enhance erectile function without any side effects, according to research published in the January/February concern of “International Journal of Impotence Research” in 2011.

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Citrulline is found in cucumbers and melons, such as watermelon and cantaloupe; nevertheless, research study is limited in showing the types of foods including citrulline that will increase nitric oxide production. Watermelon, including the flesh and rind, is a rich source of citrulline. Increasing your dietary consumption of watermelon increases your production of nitric oxide and might decrease blood concentrations of cardiovascular risk aspects.

Nitric Oxide Fundamentals Explained

Nitric oxide is a component produced in your body that assists to decrease high blood pressure, improve circulation, and increase energy. As you age, your nitric oxide levels are depleted and need to be supplemented. You can boost your nitric oxide levels by doing routine cardiovascular exercise, getting outdoors, and practicing meditation. These levels can likewise be raised if you eat healthy foods like greens and protein.

Lots of people wrongly believe of Nitric Oxide as laughing gas or a fuel for racing cars and trucks. But Nitric Oxide or NO is a substance that is produced by the body itself. When you exercise, NO quickly increases (research study, research study). It triggers the capillary to broaden, permitting blood and nutrients to rapidly reach their location.

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Studies have actually shown that NO is very important in a variety of cellular activities: Assisting memory and behavior in the exchange of information in between nerve cells in the brain. (study study, study). Supporting the immune system in fighting off bacteria and defense versus growths. Regulating blood pressure by dilating arteries (research study, study, study, study) Reducing inflammation Improving sleep quality Enhancing your senses (eg smell) Increasing strength and endurance (research study, research study) Supporting digestion system (gastrointestinal motility) Over 60,000 research studies have actually been done on Nitric Oxide in the previous twenty years.

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Nitric Oxide has cardiovascular advantages as it relaxes the arteries, and therefore manages blood pressure and blood flow. Alfred Nobel, the founder of the Nobel Prize, was prescribed nitroglycerin to assist with his heart issues. He was hesitant, since he knew that this was used in dynamite, however this chemical assisted him.

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NO is launched by the endothelium, the cells lining the within your arteries. If these cells are harmed or covered with plaque, your ability to produce NO is decreased and your total health degrades. NO unwinds and broadens the vessel wall, allowing for more blood to travel through. The more NO is released, the bigger the size of the arteries, increasing blood flow and allowing oxygen and nutrients to reach their destination faster.

And after the training NO encourages muscle healing and fiber. Hence Nitric Oxide not only ensures that you can train for longer, but also that you recuperate quicker. Yes, that’s possible. The most common method to increase the amount of NO in the body, is through exercise. When you run or lift weights your muscles need more oxygen, which is supplied by the blood.

Know more about Nitric Oxide and Cardiovascular physical health.

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Nitric oxide is an important substance for your cardiovascular and sexual health. Nitric oxide is a gas that relaxes and broadens your capillary, decreases high blood pressure and increases blood flow. Increasing production of nitric oxide secures versus cardiovascular illness and impotence. Arginine and citrulline are two amino acids that play vital roles in producing nitric oxide.  Citrulline and Nitric Oxide

A close-up of pistachios on wooden table. Credit: Valengilda/i Stock/Getty Images Arginine is a semi-essential amino acid kids require from foods and grownups can make in the body. Arginine is a precursor to nitric oxide. Increasing dietary intake of arginine from food and supplements increases production of nitric oxide. Taking arginine supplements improves blood pressure and blood circulation and reduces risk of cardiovascular disease.

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The scientists discovered arginine supplements increase nitric oxide production, reduce swelling and improve cardiovascular function. Citrulline increases nitric oxide production by increasing arginine levels, which in turn transforms into nitric oxide. Taking citrulline supplements reduces your high blood pressure. Researchers at Florida State University in Tallahassee found that oral citrulline supplementation reduces blood pressure, according to research study published in the “American Journal of High Blood Pressure” in January 2010.

The researchers report this finding is significant due to the fact that aortic high blood pressure much better reflects cardiovascular risk than brachial blood pressure, which is easier to measure and is the more traditional measurement. Arginine is found in meat, fish, dairy, eggs, nuts, seeds, whole grains, chocolate, carob and vegetables, particularly soy; nevertheless, research is limited in showing the types of foods including arginine that will increase nitric oxide production.

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Erectile dysfunction is related to low levels of nitric oxide production, due in part to dietary arginine deficiency, according to research study by researchers at the Tokyo Medical and Dental University in Japan and released in the “International Journal of Urology” in February 2008. Scientists at the Ataturk Mentor and Research Study Hospital in Ankara, Turkey, found that married men with erectile dysfunction who consume Antep pistachios improve erectile function with no negative effects, according to research released in the January/February concern of “International Journal of Impotence Research” in 2011.

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Citrulline is discovered in cucumbers and melons, such as watermelon and cantaloupe; nevertheless, research is restricted in showing the kinds of foods consisting of citrulline that will increase nitric oxide production. Watermelon, consisting of the flesh and rind, is a rich source of citrulline. Increasing your dietary consumption of watermelon increases your production of nitric oxide and may reduce blood concentrations of cardiovascular danger aspects.

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Nitric oxide is an element produced in your body that helps to decrease high blood pressure, enhance flow, and boost energy. As you age, your nitric oxide levels are diminished and need to be supplemented. You can improve your nitric oxide levels by doing routine cardiovascular exercise, getting outdoors, and practicing meditation. These levels can likewise be raised if you eat healthy foods like greens and protein.

Many people wrongly think about Nitric Oxide as chuckling gas or a fuel for racing automobiles. However Nitric Oxide or NO is a compound that is produced by the body itself. When you work out, NO rapidly increases (study, research study). It causes the capillary to widen, enabling blood and nutrients to quickly reach their destination.

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Research studies have actually shown that NO is very important in a variety of cellular activities: Helping memory and habits in the exchange of info between nerve cells in the brain. (study research study, research study). Supporting the immune system in battling bacteria and defense against growths. Regulating blood pressure by dilating arteries (research study, research study, research study, research study) Minimizing swelling Improving sleep quality Reinforcing your senses (eg smell) Increasing strength and endurance (study, research study) Supporting digestion system (intestinal motility) Over 60,000 research studies have actually been done on Nitric Oxide in the past 20 years.

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Nitric Oxide has cardiovascular benefits as it unwinds the arteries, and thus manages blood pressure and blood flow. Alfred Nobel, the creator of the Nobel Reward, was prescribed nitroglycerin to help with his heart issues. He was hesitant, because he knew that this was used in dynamite, however this chemical helped him.

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NO is launched by the endothelium, the cells lining the inside of your arteries. If these cells are damaged or covered with plaque, your capability to produce NO is reduced and your total health deteriorates. NO unwinds and widens the vessel wall, enabling more blood to pass through. The more NO is launched, the bigger the size of the arteries, increasing blood flow and permitting oxygen and nutrients to reach their destination quicker.

And after the training NO encourages muscle healing and fiber. Therefore Nitric Oxide not just makes sure that you can train for longer, but also that you recover faster. Yes, that’s possible. The most typical way to increase the amount of NO in the body, is through physical exercise. When you run or lift weights your muscles require more oxygen, which is provided by the blood.

Study more about Nitric Oxide Supplement and Cardio fitness.

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Nitric oxide is a crucial compound for your cardiovascular and sexual health. Nitric oxide is a gas that unwinds and widens your blood vessels, lowers high blood pressure and increases blood flow. Increasing production of nitric oxide safeguards against cardiovascular illness and impotence. Arginine and citrulline are two amino acids that play important functions in producing nitric oxide.

A close-up of pistachios on wooden table. Credit: Valengilda/i Stock/Getty Images Arginine is a semi-essential amino acid kids require from foods and adults can make in the body. Arginine is a precursor to nitric oxide. Increasing dietary intake of arginine from food and supplements increases production of nitric oxide. Taking arginine supplements improves blood pressure and blood circulation and minimizes risk of heart disease.  Nitric Oxide Arginine

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The researchers found arginine supplements increase nitric oxide production, reduce swelling and improve cardiovascular function. Citrulline increases nitric oxide production by increasing arginine levels, which in turn transforms into nitric oxide. Taking citrulline supplements decreases your blood pressure. Scientists at Florida State University in Tallahassee discovered that oral citrulline supplements decreases blood pressure, according to research released in the “American Journal of High Blood Pressure” in January 2010.

The scientists report this finding is substantial due to the fact that aortic high blood pressure better reflects cardiovascular threat than brachial high blood pressure, which is easier to measure and is the more standard measurement. Arginine is discovered in meat, fish, dairy, eggs, nuts, seeds, whole grains, chocolate, carob and legumes, particularly soy; however, research is limited in showing the kinds of foods including arginine that will increase nitric oxide production.

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Impotence is connected with low levels of nitric oxide production, due in part to dietary arginine shortage, according to research study by researchers at the Tokyo Medical and Dental University in Japan and published in the “International Journal of Urology” in February 2008. Scientists at the Ataturk Mentor and Research Medical Facility in Ankara, Turkey, found that family men with erectile dysfunction who take in Antep pistachios improve erectile function without any side impacts, according to research study released in the January/February issue of “International Journal of Impotence Research” in 2011.

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Citrulline is discovered in cucumbers and melons, such as watermelon and cantaloupe; however, research study is limited in showing the kinds of foods including citrulline that will increase nitric oxide production. Watermelon, including the flesh and rind, is an abundant source of citrulline. Increasing your dietary consumption of watermelon increases your production of nitric oxide and may reduce blood concentrations of cardiovascular danger aspects.

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Nitric oxide is an aspect produced in your body that assists to lower high blood pressure, improve circulation, and increase energy. As you age, your nitric oxide levels are depleted and should be supplemented. You can improve your nitric oxide levels by doing routine cardiovascular workout, getting outdoors, and practicing meditation. These levels can also be raised if you eat healthy foods like greens and protein.

Lots of people wrongly consider Nitric Oxide as laughing gas or a fuel for racing cars and trucks. But Nitric Oxide or NO is a compound that is produced by the body itself. When you exercise, NO quickly boosts (research study, study). It triggers the blood vessels to widen, enabling blood and nutrients to quickly reach their location.

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Research studies have actually revealed that NO is essential in a variety of cellular activities: Helping memory and behavior in the exchange of details in between afferent neuron in the brain. (study study, research study). Supporting the immune system in eradicating germs and defense versus growths. Controling blood pressure by dilating arteries (research study, research study, study, study) Decreasing inflammation Improving sleep quality Enhancing your senses (eg smell) Increasing strength and endurance (research study, research study) Supporting digestion system (gastrointestinal motility) Over 60,000 research studies have actually been done on Nitric Oxide in the past twenty years.

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Nitric Oxide has cardiovascular benefits as it relaxes the arteries, and therefore manages high blood pressure and blood circulation. Alfred Nobel, the founder of the Nobel Prize, was recommended nitroglycerin to aid with his heart issues. He was hesitant, because he knew that this was used in dynamite, however this chemical assisted him.

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NO is launched by the endothelium, the cells lining the inside of your arteries. If these cells are damaged or covered with plaque, your ability to produce NO is minimized and your overall health degrades. NO unwinds and widens the vessel wall, allowing for more blood to go through. The more NO is released, the larger the diameter of the arteries, increasing blood circulation and permitting oxygen and nutrients to reach their destination faster.

And after the training NO encourages muscle recovery and fiber. Hence Nitric Oxide not just guarantees that you can train for longer, however also that you recover faster. Yes, that’s possible. The most typical way to increase the amount of NO in the body, is through exercise. When you run or lift weights your muscles need more oxygen, which is provided by the blood.

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Nitric oxide is an important compound for your cardiovascular and sexual health. Nitric oxide is a gas that relaxes and widens your capillary, decreases blood pressure and increases blood flow. Increasing production of nitric oxide safeguards against heart disease and impotence. Arginine and citrulline are two amino acids that play important functions in producing nitric oxide.

A close-up of pistachios on wooden table. Credit: Valengilda/i Stock/Getty Images Arginine is a semi-essential amino acid kids require from foods and grownups can make in the body. Arginine is a precursor to nitric oxide. Increasing dietary consumption of arginine from food and supplements increases production of nitric oxide. Taking arginine supplements enhances high blood pressure and blood flow and decreases risk of cardiovascular disease.

More About Nitric Oxide

The scientists found arginine supplements increase nitric oxide production, lower swelling and improve cardiovascular function. Citrulline increases nitric oxide production by increasing arginine levels, which in turn transforms into nitric oxide. Taking citrulline supplements lowers your blood pressure. Researchers at Florida State University in Tallahassee discovered that oral citrulline supplements lowers blood pressure, according to research study published in the “American Journal of High Blood Pressure” in January 2010.  Cardio Cocktail

The researchers report this finding is substantial because aortic blood pressure better shows cardiovascular danger than brachial blood pressure, which is much easier to measure and is the more conventional measurement. Arginine is discovered in meat, fish, dairy, eggs, nuts, seeds, entire grains, chocolate, carob and vegetables, especially soy; however, research study is restricted in demonstrating the types of foods including arginine that will increase nitric oxide production.

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Erectile dysfunction is connected with low levels of nitric oxide production, due in part to dietary arginine shortage, according to research by scientists at the Tokyo Medical and Dental University in Japan and published in the “International Journal of Urology” in February 2008. Scientists at the Ataturk Teaching and Research Hospital in Ankara, Turkey, found that married men with impotence who consume Antep pistachios improve erectile function with no negative effects, according to research study published in the January/February problem of “International Journal of Impotence Research” in 2011.

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Citrulline is found in cucumbers and melons, such as watermelon and cantaloupe; however, research study is limited in demonstrating the kinds of foods including citrulline that will increase nitric oxide production. Watermelon, consisting of the flesh and rind, is an abundant source of citrulline. Increasing your dietary intake of watermelon increases your production of nitric oxide and might reduce blood concentrations of cardiovascular threat factors.

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Nitric oxide is an element produced in your body that helps to decrease blood pressure, enhance blood circulation, and boost energy. As you age, your nitric oxide levels are diminished and need to be supplemented. You can increase your nitric oxide levels by doing routine cardiovascular workout, getting outdoors, and practicing meditation. These levels can likewise be raised if you eat healthy foods like greens and protein.

Lots of people wrongly think of Nitric Oxide as laughing gas or a fuel for racing automobiles. However Nitric Oxide or NO is a substance that is produced by the body itself. When you work out, NO quickly increases (research study, study). It triggers the capillary to widen, permitting blood and nutrients to rapidly reach their destination.

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Studies have revealed that NO is essential in a variety of cellular activities: Helping memory and habits in the exchange of details in between nerve cells in the brain. (study research study, research study). Supporting the immune system in combating bacteria and defense against growths. Managing high blood pressure by dilating arteries (study, study, research study, research study) Minimizing swelling Improving sleep quality Strengthening your senses (eg odor) Increasing strength and endurance (study, research study) Supporting gastrointestinal system (intestinal motility) Over 60,000 studies have been done on Nitric Oxide in the past twenty years.

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Nitric Oxide has cardiovascular benefits as it relaxes the arteries, and therefore manages high blood pressure and blood circulation. Alfred Nobel, the creator of the Nobel Reward, was recommended nitroglycerin to assist with his heart problems. He was skeptical, due to the fact that he understood that this was used in dynamite, however this chemical helped him.

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NO is released by the endothelium, the cells lining the within your arteries. If these cells are damaged or covered with plaque, your ability to produce NO is decreased and your overall health weakens. NO relaxes and expands the vessel wall, permitting for more blood to travel through. The more NO is launched, the larger the size of the arteries, increasing blood flow and permitting oxygen and nutrients to reach their location faster.

And after the training NO motivates muscle recovery and fiber. Thus Nitric Oxide not only guarantees that you can train for longer, however also that you recover quicker. Yes, that’s possible. The most common way to increase the quantity of NO in the body, is through exercise. When you run or lift weights your muscles need more oxygen, which is provided by the blood.

Know more about Nitric Oxide and Cardio physical health.