L-arginine is one of the most metabolically versatile amino acids. In addition to its role in the synthesis of nitric oxide, l-arginine serves as a precursor for the synthesis of polyamines, proline, glutamate, creatine, agmatine, and urea. Several human and experimental animal studies have indicated that exogenous l-arginine intake has multiple beneficial pharmacological effects when taken in doses larger than normal dietary consumption.
4.1 Nitric Oxide and NOS
L-arginine (2-amino-5-guanidino-pentanoic acid) is a conditionally essential, proteinogenic amino acid that is a natural constituent of dietary proteins ( 1 ). Besides its role in protein metabolism, l-arginine is involved in various metabolic pathways, such as the synthesis of creatine, l-ornithine, l-glutamate, and polyamines ( 2 ). Decarboxylation of l-arginine can produce agmatine, a biogenic amine metabolite. L-arginine is also involved in protein degradation by the ubiquitin-proteasome pathway ( 2 ).
L-arginine is a semi-essential amino acid that is particularly rich in certain foods such as meats and nuts. L-arginine is the substrate for the enzyme nitric oxide synthase (nos), which is responsible for the production of nitric oxide. Nitric oxide produced in the vascular endothelium by endothelial nos is responsible for smooth muscle cell relaxation and essential for reducing blood pressure.
4.3 Blood Flow and Pressure
Being anti-inflammatory in nature, l-arginine helps reduce the level of inflammation in the blood vessels. Individuals suffering from coronary heart diseases are directed to consume l-arginine supplements as it helps improve cardiovascular health and function. L-arginine helps reduce high blood pressure and improves blood flow by unblocking the clogged arteries.
By improving blood flow in the body, some proponents claim that l-arginine may help heart conditions, such as chest pain (angina), high blood pressure, leg cramping, and weakness due to obstructed arteries (a condition known as intermittent claudication), and erectile dysfunction (ed). Some people use l-arginine to boost the immune system, improve athletic performance, shorten recovery time after surgery, and promote weight loss.
The two main functions of l-arginine in the human body are to make nitric oxide and to create proteins to build muscle and other tissues. For both of these paths, there are many health benefits that can be seen. Lowered blood pressure
when nitric oxide is in the blood, it helps to dilate, which means to open up, the blood vessels.
6 L-Arginine Health Benefits Dosage, Side Effects
L-arginine is a conditionally essential amino acid that plays a role in building the proteins in our body. Although arginine is synthesized in the body, it is not made in sufficient quantities to meet the metabolic requirements during certain health conditions. In such cases, l-arginine supplements may help. This nutritionally essential amino acid has many health benefits and has been used to treat several ailments.
This nutritionally essential amino acid has many health benefits and has been used to treat several ailments. It may treat heart disease, reduce high blood pressure, ease inflammation in the digestive tract, aid diabetes treatment, heal wounds, and boost immune health. This article discusses the potential health benefits, dosage, risks, and side effects of l-arginine. Read on to know more.